Adapted from the 1951 non-fiction account by psychoanalyst Georges Devereux, “Psychotherapy Of A Plains Indian,” the film follows the true story of Picard (Del Toro), a Plains Indian of the Blackfeet nation, as he returns from WWII and begins experiencing unexplainable symptoms shortly thereafter. He travels to the famous Winter Hospital in Topeka, Kansas, where he meets Devereux (Amalric), thus beginning a professional and personal friendship guided by compassion and understanding of Native American culture.